The station was built when construction of the railway line began south of Sloviansk in 1868 and the Kramatorsk site was in a suitable position, being at a junction of lines. At first the railway was a single track. It was completed in 1879 and the building, now made of stone, had two floors. In the same years the settlement grew.
During World War II the historical building was destroyed and in 1952 it was rebuilt according to the design of architect Syromyatnikov.
On April 8, 2022, at 10:45 AM, the Russian Nazis launched a deliberate strike with two Point-U missiles at the station building. At that time, there were about 4,000 people at the station waiting to be evacuated. Mostly women, children and the elderly… As a result of this horrific war crime, 59 people died, including 7 children. About a hundred people were injured.